Tangle diseases and the tau haplotypes

John Hardy, Alan Pittman, Amanda Myers, Hon Chung Fung, Rohan De Silva, Jaime Duckworth

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Neurofibrillary tangles are found in many neurologic diseases. Here we review the unusual characteristics of the MAPT locus, which shows genetic association with many of these diseases and in Caucasian populations, is the largest stretch of linkage disequilibrium in the genome. We discuss the reason for this disequilibrium, its evolutionary history, and the role of genetic variability at MAPT in the etiology of tauopathies.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalAlzheimer disease and associated disorders
Issue number1
StatePublished - Jan 2006
Externally publishedYes


  • Neurofibrillary tangles
  • Tangle diseases
  • Tau haplotypes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)


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