Synthetic lh-releasing hormone (LH-RH) administered to normal men by different routes

David Gonzalez-Barcena, Abba J. Kastin Dr, Don S. Schalch, Jose A. Bermudez, Daniel Lee, Akira Arimura, Juan Ruelas, Ismael Zepeda, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Synthetic LH releasing hormone (LH RH) was administered to 54 healthy adult men in doses of 3, 6, 12.5, 25, 50, 100, 250, and 500 μg. Each dose was given as a single rapid iv injection and, in addition, the doses of 25 and 250 μg LH RH were given im, sc, and as a 4 hr iv infusion. Plasma gonadotropin levels increased with all of the doses tested and routes of administration, ranging from 700-1400% of LH and 200-600% for FSH. Some subjects in each group also showed a 50-100% increase in the levels of plasma testosterone and 17 OH progesterone.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Sep 1973
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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