TY - JOUR
T1 - Synthetic lh-releasing hormone (LH-RH) administered to normal men by different routes
AU - Gonzalez-Barcena, David
AU - Kastin Dr, Abba J.
AU - Schalch, Don S.
AU - Bermudez, Jose A.
AU - Lee, Daniel
AU - Arimura, Akira
AU - Ruelas, Juan
AU - Zepeda, Ismael
AU - Schally, Andrew V.
PY - 1973/9
Y1 - 1973/9
N2 - Synthetic LH releasing hormone (LH RH) was administered to 54 healthy adult men in doses of 3, 6, 12.5, 25, 50, 100, 250, and 500 μg. Each dose was given as a single rapid iv injection and, in addition, the doses of 25 and 250 μg LH RH were given im, sc, and as a 4 hr iv infusion. Plasma gonadotropin levels increased with all of the doses tested and routes of administration, ranging from 700-1400% of LH and 200-600% for FSH. Some subjects in each group also showed a 50-100% increase in the levels of plasma testosterone and 17 OH progesterone.
AB - Synthetic LH releasing hormone (LH RH) was administered to 54 healthy adult men in doses of 3, 6, 12.5, 25, 50, 100, 250, and 500 μg. Each dose was given as a single rapid iv injection and, in addition, the doses of 25 and 250 μg LH RH were given im, sc, and as a 4 hr iv infusion. Plasma gonadotropin levels increased with all of the doses tested and routes of administration, ranging from 700-1400% of LH and 200-600% for FSH. Some subjects in each group also showed a 50-100% increase in the levels of plasma testosterone and 17 OH progesterone.
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U2 - 10.1210/jcem-37-3-481
DO - 10.1210/jcem-37-3-481
M3 - Article
C2 - 4594410
AN - SCOPUS:0015808502
VL - 37
SP - 481
EP - 484
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
ER -