TY - JOUR
T1 - Relationship of depression to diabetes types 1 and 2
T2 - Epidemiology, biology, and treatment
AU - Musselman, Dominique L.
AU - Betan, Ephi
AU - Larsen, Hannah
AU - Phillips, Lawrence S.
N1 - Funding Information:
Aspects of this work were presented at the conference, “The Diagnosis and Treatment of Mood Disorders in the Medically Ill,” November 12–13, 2002 in Washington, DC. The conference was sponsored by the Depression and Bipolar Support Alliance through unrestricted educational grants provided by Abbott Laboratories, Bristol-Myers Squibb Company, Cyberonics, Inc., Eli Lilly and Company, Forest Laboratories, Inc., GlaxoSmithKline, Janssen Pharmaceutica Products, Organon Inc., Pfizer Inc, and Wyeth Pharmaceuticals.
Funding Information:
This research was supported by grants RR-00039 from the National Institutes of Health, Bethesda, Maryland and HS-07922 (LSP) and DK063302 (DLM). We are grateful for the assistance of Barbara Rothbaum, Ph.D., Ms. Alice Huang, Mr. Brett Galvin, Ms. Mary Lou Mojonnier, and the nursing and laboratory staff of the Emory General Clinical Research Center, Emory University Hospital, and the Diabetes Clinic at Grady Memorial Hospital. We apologize to those colleagues whose work could not be cited due to space restraints.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - This article reviews the rapidly accumulating literature on the relationship between mood disorders and diabetes mellitus. Recent studies have demonstrated that depression and its associated symptoms constitute a major risk factor in the development of type 2 diabetes and may accelerate the onset of diabetes complications. Since the mid-1980s, multiple longitudinal and cross-sectional studies have scrutinized the association of diabetes with depressive symptoms and major depression. Utilizing the search terms depressive disorders, psychiatry, diabetes, and pathophysiology in MEDLINE searches (1966-2003), this article reviews studies investigating pathophysiological alterations related to glucose intolerance and diabetes in depressed patients. The few randomized, controlled studies of treatment of depression in patients with diabetes are also described. Short-term treatment of depression in patients with diabetes improves their dysphoria and other signs and symptoms of depression. Future research will confirm whether response to psychotherapy and/or psychopharmacologic treatment improves glucose control, encourages compliance with diabetes treatment, and perhaps even increases longevity.
AB - This article reviews the rapidly accumulating literature on the relationship between mood disorders and diabetes mellitus. Recent studies have demonstrated that depression and its associated symptoms constitute a major risk factor in the development of type 2 diabetes and may accelerate the onset of diabetes complications. Since the mid-1980s, multiple longitudinal and cross-sectional studies have scrutinized the association of diabetes with depressive symptoms and major depression. Utilizing the search terms depressive disorders, psychiatry, diabetes, and pathophysiology in MEDLINE searches (1966-2003), this article reviews studies investigating pathophysiological alterations related to glucose intolerance and diabetes in depressed patients. The few randomized, controlled studies of treatment of depression in patients with diabetes are also described. Short-term treatment of depression in patients with diabetes improves their dysphoria and other signs and symptoms of depression. Future research will confirm whether response to psychotherapy and/or psychopharmacologic treatment improves glucose control, encourages compliance with diabetes treatment, and perhaps even increases longevity.
KW - Antidepressant
KW - Depression
KW - Diabetes
KW - Glycemic control
KW - Psychotherapy
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U2 - 10.1016/S0006-3223(03)00569-9
DO - 10.1016/S0006-3223(03)00569-9
M3 - Review article
C2 - 12893107
AN - SCOPUS:0141832614
VL - 54
SP - 317
EP - 329
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 3
ER -
