Mitochondrial encephalomyopathies

S. DiMauro, E. Bonilla, A. Lombes, S. Shanske, C. Minetti, C. T. Moraes

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


The mitochondrial diseases present with great heterogeneity. They are often multisystemic and vary considerably in age at onset, distribution of weakness, severity, and course. Only nonthyroidal hypermetabolism has a distinctive clinical presentation. Therefore, attempts at classification have generated some controversy. This article discusses the general classification that takes into account genetic and biochemical features, which has resulted from the fast pace of biochemical and molecular genetic investigations.

Original languageEnglish (US)
Pages (from-to)483-506
Number of pages24
JournalNeurologic Clinics
Issue number3
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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