INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE

S. R. Bloom; C. H. Mortimer; M. O. Thorner; G. M. Besser; R. Hall; A. Gomez-Pan; V. M. Roy; R. C.G. Russell; D. H. Coy; A. T. Kastin; A. V. Schally

doi:10.1016/S0140-6736(74)90869-1

INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE

S. R. Bloom, C. H. Mortimer, M. O. Thorner, G. M. Besser, R. Hall, A. Gomez-Pan, V. M. Roy, R. C.G. Russell, D. H. Coy, A. T. Kastin, A. V. Schally

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Abstract

The hypothalamic polypeptide growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastrin release in all subjects studied. In normal subjects and in patients with acromegaly during a standard food stimulus a G.H.- R.I.H. infusion completely suppressed gastrin release, and immediately after the infusion was stopped gastrin levels rose sharply to exceed control values. Two patients with pernicious anæmia demonstrated a rapid fall in plasma-gastrin during G.H.-R.I.H. infusion, and in a patient with Zollinger-Ellison syndrome a 20-minute G.H.-R.I.H. infusion greatly lowered plasma-gastrin concentrations and almost totally suppressed gastric-acid production.

Original language	English (US)
Pages (from-to)	1106-1109
Number of pages	4
Journal	The Lancet
Volume	304
Issue number	7889
DOIs	https://doi.org/10.1016/S0140-6736(74)90869-1
State	Published - Nov 9 1974
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(74)90869-1

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title = "INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE",

abstract = "The hypothalamic polypeptide growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastrin release in all subjects studied. In normal subjects and in patients with acromegaly during a standard food stimulus a G.H.- R.I.H. infusion completely suppressed gastrin release, and immediately after the infusion was stopped gastrin levels rose sharply to exceed control values. Two patients with pernicious an{\ae}mia demonstrated a rapid fall in plasma-gastrin during G.H.-R.I.H. infusion, and in a patient with Zollinger-Ellison syndrome a 20-minute G.H.-R.I.H. infusion greatly lowered plasma-gastrin concentrations and almost totally suppressed gastric-acid production.",

author = "Bloom, {S. R.} and Mortimer, {C. H.} and Thorner, {M. O.} and Besser, {G. M.} and R. Hall and A. Gomez-Pan and Roy, {V. M.} and Russell, {R. C.G.} and Coy, {D. H.} and Kastin, {A. T.} and Schally, {A. V.}",

year = "1974",

month = nov,

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doi = "10.1016/S0140-6736(74)90869-1",

language = "English (US)",

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T1 - INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE

AU - Bloom, S. R.

AU - Mortimer, C. H.

AU - Thorner, M. O.

AU - Besser, G. M.

AU - Hall, R.

AU - Gomez-Pan, A.

AU - Roy, V. M.

AU - Russell, R. C.G.

AU - Coy, D. H.

AU - Kastin, A. T.

AU - Schally, A. V.

PY - 1974/11/9

Y1 - 1974/11/9

N2 - The hypothalamic polypeptide growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastrin release in all subjects studied. In normal subjects and in patients with acromegaly during a standard food stimulus a G.H.- R.I.H. infusion completely suppressed gastrin release, and immediately after the infusion was stopped gastrin levels rose sharply to exceed control values. Two patients with pernicious anæmia demonstrated a rapid fall in plasma-gastrin during G.H.-R.I.H. infusion, and in a patient with Zollinger-Ellison syndrome a 20-minute G.H.-R.I.H. infusion greatly lowered plasma-gastrin concentrations and almost totally suppressed gastric-acid production.

AB - The hypothalamic polypeptide growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastrin release in all subjects studied. In normal subjects and in patients with acromegaly during a standard food stimulus a G.H.- R.I.H. infusion completely suppressed gastrin release, and immediately after the infusion was stopped gastrin levels rose sharply to exceed control values. Two patients with pernicious anæmia demonstrated a rapid fall in plasma-gastrin during G.H.-R.I.H. infusion, and in a patient with Zollinger-Ellison syndrome a 20-minute G.H.-R.I.H. infusion greatly lowered plasma-gastrin concentrations and almost totally suppressed gastric-acid production.

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JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 7889

ER -

INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE

Abstract

ASJC Scopus subject areas

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