Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat spinal cord

I. Merchenthaler, M. A. Hynes, S. Vigh, A. V. Shally, P. Petrusz

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


The presence of corticotropin releasing factor (CRF)-immunoreactive nerve fibers and cell bodies in the spinal cord is demonstrated. Immunopositive fibers were found in the lateral column of the white matter, in laminae I, V-IV, X, and in the intermediolateral column of the spinal cord. Complete transection of the spinal cord showed that the majority of the fibers in the lateral funiculus formed an ascending pathway; however, a few descending fibers were also detected. Hypophysectomy resulted in enhanced immunoreactivity to the fibers and staining of CRF-immunoreactive cell bodies in laminae V-VII, X, and in the intermediolateral sympathetic column. The results suggest that CRF is not merely an ACTH releasing factor, but also a regulatory peptide which may be involved in several stress-related neural responses.

Original languageEnglish (US)
Pages (from-to)373-377
Number of pages5
JournalBrain research
Issue number2
StatePublished - Sep 26 1983
Externally publishedYes


  • hypophysectomy
  • intermediolateral column
  • lateral funiculus
  • marginal zone
  • spinal cord
  • spinal cord transection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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