Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation

Sergio F. Santiago, Werviston De Faria, Taqi F. Toufeeq Khan, Carlos E. Gandia, Evangelos P. Misiakos, Luis Ferrer, Phillip Ruiz, Laurence Coleman, Hugo F. Fernandez, Joshua Miller, Camillo Ricordi, Andreas G. Tzakis

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


We introduced the heterotopic vascularized sternum transplant as a more simple and pure alternative to allogeneic hind limb transplantation for the study of bone marrow transplantation. We report the clinical and histopathological manifestations after transplantation of syngeneic and allogeneic sternal grafts with and without immunossupression with FK-506. Syngeneic grafts maintained normal histology, whereas allografts showed rejection, which was prevented by FK-506. FK-506-treated allografts developed chimerism that was present throughout the observation period. Transplantation of the sternum may be a valuable model to study vascularized bone marrow transplantation and its effects on repopulation of bone marrow of the host, chimerism, and tolerance.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
Issue number7
StatePublished - 1999

ASJC Scopus subject areas

  • Surgery


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