Gadolinium-DTPA-enhanced Magnetic Resonance Imaging in Optic Neuropathies

John Guy, Anthony Mancuso, Ronald G. Quisling, Roy Beck, Mark Moster

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.

Original languageEnglish (US)
Pages (from-to)592-600
Number of pages9
Issue number5
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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