Functional implications of calcium permeability of the channel formed by pannexin 1

Fabien Vanden Abeele, Gabriel Bidaux, Dmitri Gordienko, Benjamin Beck, Yuri V. Panchin, Ancha V. Baranova, Dmitry V. Ivanov, Roman Skryma, Natalia Prevarskaya

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca2+-permeable gap junction channels between adjacent cells, thus, allowing direct intercellular Ca2+ diffusion and facilitating inter cellular Ca2+ wave propagation. More intriguingly, our results strongly suggest that PanX1 may also form Ca2+-permeable channels in the endoplasmic reticulum (ER). These channels contribute to the ER Ca 2+ leak and thereby affect the ER Ca2+ load. Because leakage remains the most enigmatic of those processes involved in intracellular calcium homeostasis, and the molecular nature of the leak channels is as yet unknown, the results of this work provide new insight into calcium signaling mechanisms. These results imply that for vertebrates, a new protein family, referred to as pannexins, may not simply duplicate the connexin function but may also provide additional pathways for intra- and intercellular calcium signaling and homeostasis.

Original languageEnglish (US)
Pages (from-to)535-546
Number of pages12
JournalJournal of Cell Biology
Issue number4
StatePublished - Aug 14 2006

ASJC Scopus subject areas

  • Cell Biology


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