TY - JOUR
T1 - Finding specific genes that cause autism
T2 - A combination of approaches will be needed to maximize power
AU - Folstein, Susan E.
AU - Bisson, Erica
AU - Santangelo, Susan L.
AU - Piven, Joseph
N1 - Funding Information:
This research was supported by National Institute of Mental Health Grants MH 55135 (S.E.F.) and MH 01338 (S.L.S.).
PY - 1998
Y1 - 1998
N2 - Although autism is clearly inherited, it may be challenging to find the genes involved: The mechanism of inheritance is unknown, families with an autistic child are usually small, parent-child pairs are rare, and a fairly large number of genes may be involved, some or all of which may have a small effect on the phenotype. We discuss several strategies for finding genes, all of which may be used in combination to find the relevant genes.
AB - Although autism is clearly inherited, it may be challenging to find the genes involved: The mechanism of inheritance is unknown, families with an autistic child are usually small, parent-child pairs are rare, and a fairly large number of genes may be involved, some or all of which may have a small effect on the phenotype. We discuss several strategies for finding genes, all of which may be used in combination to find the relevant genes.
KW - Extremely discordant sibling pairs
KW - Genetic linkage
KW - Genetic methods
KW - Sib-pair analysis
UR - http://www.scopus.com/inward/record.url?scp=0032461804&partnerID=8YFLogxK
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U2 - 10.1023/A:1026008606672
DO - 10.1023/A:1026008606672
M3 - Review article
C2 - 9813779
AN - SCOPUS:0032461804
VL - 28
SP - 439
EP - 445
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 5
ER -