Design and fabrication of CD-like microfluidic platforms for diagnostics: Polymer-based microfabrication

James Lee, Marc J. Madou, Kurt W. Koelling, Sylvia Daunert, Siyi Lai, Guan Koh, Yi Je Juang, Yumin Lu, Liyong Yu

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Several microfabrication methods for polymer-based CD microfluidic platforms are presented in this paper. For prototyping, both traditional CNC-machining and photolithography techniques were used. For mass production, mold inserts were made by CNC-machining of tool steel and LIGA-like processes such as UV photolithography, photolithography/electroplating, and photolithography/deep reactive ion etching (DRIE). Several molding methods were tried, including liquid resin casting, thin wall injection molding, and hot embossing. Advantages and disadvantages of each method are explained. Plastic bonding for microfluidic platforms is also briefly discussed.

Original languageEnglish (US)
Article number381088
Pages (from-to)339-351
Number of pages13
JournalBiomedical Microdevices
Issue number4
StatePublished - 2001
Externally publishedYes


  • CNC-machining
  • Deep reactive ion etching
  • Electroplating
  • Hot embossing
  • Liquid resin casting
  • Microfabrication
  • Photolithography
  • Thin wall injection molding

ASJC Scopus subject areas

  • Genetics
  • Medicine (miscellaneous)
  • Neuroscience(all)


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