Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men

W. J. Maierhofer; R. W. Gray; H. S. Cheung; J. Lemann

doi:10.1038/ki.1983.193

Bone resorption stimulated by elevated serum 1,25-(OH)₂-vitamin D concentrations in healthy men

W. J. Maierhofer, R. W. Gray, H. S. Cheung, J. Lemann

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)₂-D concentrations, Ca and PO₄ balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)₂-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO₄ balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)₂-D concentrations in healthy men eating low Ca diets stimulate bone resorption.

Original language	English (US)
Pages (from-to)	555-560
Number of pages	6
Journal	Kidney international
Volume	24
Issue number	4
DOIs	https://doi.org/10.1038/ki.1983.193
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Nephrology

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10.1038/ki.1983.193

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@article{db63acefc0204138a74929bd41f07a5c,

title = "Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men",

abstract = "We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)2-D concentrations, Ca and PO4 balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)2-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO4 balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)2-D concentrations in healthy men eating low Ca diets stimulate bone resorption.",

author = "Maierhofer, {W. J.} and Gray, {R. W.} and Cheung, {H. S.} and J. Lemann",

note = "Funding Information: Acknowledgements This work was supported in part by United States Public Health",

year = "1983",

doi = "10.1038/ki.1983.193",

language = "English (US)",

volume = "24",

pages = "555--560",

journal = "Kidney International",

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T1 - Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men

AU - Maierhofer, W. J.

AU - Gray, R. W.

AU - Cheung, H. S.

AU - Lemann, J.

N1 - Funding Information: Acknowledgements This work was supported in part by United States Public Health

PY - 1983

Y1 - 1983

N2 - We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)2-D concentrations, Ca and PO4 balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)2-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO4 balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)2-D concentrations in healthy men eating low Ca diets stimulate bone resorption.

AB - We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)2-D concentrations, Ca and PO4 balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)2-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO4 balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)2-D concentrations in healthy men eating low Ca diets stimulate bone resorption.

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JO - Kidney International

JF - Kidney International

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Bone resorption stimulated by elevated serum 1,25-(OH)₂-vitamin D concentrations in healthy men

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