Bleb rupture following filtering surgery with mitomycin-C: Clinicopathologic correlations

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21 Scopus citations


A 91-year-old woman with a complete rupture of her mitomycin-C filtration bleb associated with eye rubbing while crying was examined. An 18- mm soft contact lens was placed preoperatively to reform the anterior chamber and the patient underwent a conjunctival advancement. Histopathology of the free conjunctival specimen revealed a stratified squamous epithelium with marked attenuation of the subepithelial tissue in the area treated with mitomycin-C. Bleb rupture may be associated with minimal physical trauma following guarded filtration surgery. Successful visual rehabilitation is possible with conjunctival advancement, yet long-term survival of the bleb is poor.

Original languageEnglish (US)
Pages (from-to)876-877
Number of pages2
JournalOphthalmic Surgery and Lasers
Issue number10
StatePublished - Oct 1 1996

ASJC Scopus subject areas

  • Ophthalmology


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