Autism: Definition, Neurobiology, Screening, Diagnosis

Isabelle Rapin, Roberto F. Tuchman

Research output: Contribution to journalReview articlepeer-review

178 Scopus citations


Autism (ie, the autism spectrum disorders) is now recognized in 1 in 150 children. This article highlights the definition, neurobiology, screening, and diagnosis of autism. The genetics, immunology, imaging, and neurophysiology of autism are reviewed, with particular emphasis on areas that impact pediatricians. Early recognition of the social deficits that characterize autism is key to maximizing the potential of these children.

Original languageEnglish (US)
Pages (from-to)1129-1146
Number of pages18
JournalPediatric clinics of North America
Issue number5
StatePublished - Oct 2008
Externally publishedYes


  • Autism
  • Brain imaging
  • Connectivity
  • Electrophysiology
  • Epidemiology
  • Genetics
  • Immunology
  • Sensorimotor deficits
  • Synapse

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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