Association of vitamin b6 status with parameters of immune function in early HIV-1 infection

Marianna K. Baum, Emilio Mantero-Atienza, Gail Shor-Posner, Mary Ann Fletcher, Robert Morgan, Carl Eisdorfer, Howerde E. Sauberlich, Philip E. Cornwell, Richard S. Beach

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Nutritional deficiencies have been documented to affect immune function. The present study indicates that vitamin B6 deficiency is prevalent in CDC stage III HIV-1-infected subjects, despite adequate dietary vitamin B6 intake. As vitamin B6 deficiency has been previously shown to affect immune function, these relatively asymptomatic HIV-1-infected patients were examined for evidence of a relationship between vitamin B6 deficiency and immune dysregulation. Vitamin B6 status in HIV-1-infected subjects was significantly associated with functional parameters of immunity [multivariate F(3,36) = 3.70, p ≤ 0.02]. Additional analyses indicated that overtly deficient participants exhibited significantly decreased lymphocyte responsiveness to the mitogens phytohemagglutinin and pokeweed, and reduced natural killer cell cytotoxicity, compared to subjects with clearly adequate vitamin B6 status (χ2 = 8.78, df = 3, p < 0.04). Vitamin B6 status was not related to immune cell subpopulations, e.g., CD4, CD8 cell number, or level of serum immunoglobulins. The results of this study indicate that while vitamin B6 status is not a primary etiological factor in HIV-1-related immunological dysregulation, it appears to be an important cofactor of immune function.

Original languageEnglish (US)
Pages (from-to)1122-1132
Number of pages11
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number11
StatePublished - Nov 1991
Externally publishedYes


  • HIV-1 infection
  • Immunity
  • Nutrition
  • Vitamin B

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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