Alzheimer II Astrocytosis Following Methionine Sulfoximine

Jorge A. Gutierrez, Michael D. Norenberg

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


A light microscopic study was performed during the preictal period following the administration of methionine sulfoximine (MSO) to adult rats. The principal morphologic observation was the development of Alzheimer II astrocytes in gray matter, suggesting that the metabolic abnormality induced by MSO is initially confined to the astrocyte. In view of the association of the Alzheimer II astrocyte with hyperammonemic states, the drug toxicity may be secondary to the presence of ammonia. A possible mechanism involves astrocytes in the development of seizures produced by MSO.

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalArchives of neurology
Issue number2
StatePublished - Feb 1975
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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