TY - JOUR
T1 - Ability of cirrus HD-OCT optic nerve head parameters to discriminate normal from glaucomatous eyes
AU - Mwanza, Jean Claude
AU - Oakley, Jonathan D.
AU - Budenz, Donald L.
AU - Anderson, Douglas R.
N1 - Funding Information:
Supported by an unrestricted grant to the Bascom Palmer Eye Institute , University of Miami Miller School of Medicine , from the Research to Prevent Blindness, Inc. , New York, NY; an unrestricted grant from Carl Zeiss Meditec, Inc. , Dublin, CA, and Core Grant; and National Institutes of Health P30 EY014801 awarded to the Bascom Palmer Eye Institute by the National Institutes of Health , Bethesda, MD.
PY - 2011/2
Y1 - 2011/2
N2 - Purpose To determine the ability of optic nerve head (ONH) parameters measured with spectral domain Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA) to discriminate between normal and glaucomatous eyes and to compare them with the discriminating ability of peripapillary retinal nerve fiber layer (RNFL) thickness measurements performed with Cirrus HD-OCT. Design Evaluation of diagnostic test or technology. Participants Seventy-three subjects with glaucoma and 146 age-matched normal subjects. Methods Peripapillary ONH parameters and RNFL thickness were measured in 1 randomly selected eye of each participant within a 200×200 pixel A-scan acquired with Cirrus HD-OCT centered on the ONH. Main Outcome Measures Optic nerve head topographic parameters, peripapillary RNFL thickness, and area under receiver operating characteristic curves (AUCs). Results To distinguish normal from glaucomatous eyes, regardless of disease stage, the 6 best parameters (expressed as AUC) were vertical rim thickness (VRT, 0.963), rim area (0.962), RNFL thickness at clock-hour 7 (0.957), RNFL thickness of the inferior quadrant (0.953), vertical cup-to-disc ratio (VCDR, 0.951), and average RNFL thickness (0.950). The AUC for distinguishing between normal eyes and eyes with mild glaucoma was greatest for RNFL thickness of clock-hour 7 (0.918), VRT (0.914), rim area (0.912), RNFL thickness of inferior quadrant (0.895), average RNFL thickness (0.893), and VCDR (0.890). There were no statistically significant differences between AUCs for the best ONH parameters and RNFL thickness measurements (P>0.05). Conclusions Cirrus HD-OCT ONH parameters are able to discriminate between normal eyes and eyes with glaucoma or even mild glaucoma. There is no difference in the ability of ONH parameters and RNFL thickness measurement, as measured with Cirrus OCT, to distinguish between normal and glaucomatous eyes. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.
AB - Purpose To determine the ability of optic nerve head (ONH) parameters measured with spectral domain Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA) to discriminate between normal and glaucomatous eyes and to compare them with the discriminating ability of peripapillary retinal nerve fiber layer (RNFL) thickness measurements performed with Cirrus HD-OCT. Design Evaluation of diagnostic test or technology. Participants Seventy-three subjects with glaucoma and 146 age-matched normal subjects. Methods Peripapillary ONH parameters and RNFL thickness were measured in 1 randomly selected eye of each participant within a 200×200 pixel A-scan acquired with Cirrus HD-OCT centered on the ONH. Main Outcome Measures Optic nerve head topographic parameters, peripapillary RNFL thickness, and area under receiver operating characteristic curves (AUCs). Results To distinguish normal from glaucomatous eyes, regardless of disease stage, the 6 best parameters (expressed as AUC) were vertical rim thickness (VRT, 0.963), rim area (0.962), RNFL thickness at clock-hour 7 (0.957), RNFL thickness of the inferior quadrant (0.953), vertical cup-to-disc ratio (VCDR, 0.951), and average RNFL thickness (0.950). The AUC for distinguishing between normal eyes and eyes with mild glaucoma was greatest for RNFL thickness of clock-hour 7 (0.918), VRT (0.914), rim area (0.912), RNFL thickness of inferior quadrant (0.895), average RNFL thickness (0.893), and VCDR (0.890). There were no statistically significant differences between AUCs for the best ONH parameters and RNFL thickness measurements (P>0.05). Conclusions Cirrus HD-OCT ONH parameters are able to discriminate between normal eyes and eyes with glaucoma or even mild glaucoma. There is no difference in the ability of ONH parameters and RNFL thickness measurement, as measured with Cirrus OCT, to distinguish between normal and glaucomatous eyes. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.
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U2 - 10.1016/j.ophtha.2010.06.036
DO - 10.1016/j.ophtha.2010.06.036
M3 - Article
C2 - 20920824
AN - SCOPUS:79551570246
VL - 118
SP - 241-248.e1
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 2
ER -