pH regulation of cell surface receptors

Project: Research project

Project Details

Description

PROJECT NARRATIVE Changes in physiologic pH, particularly acidotic signals, accompany a variety of biological processes and clinical pathologies. The goal of our proposed research program is to pursue an in-depth understanding of how these pH signals regulate the biology and pharmacology of G protein-coupled receptors (GPCRs), the largest and most therapeutically targeted class of transmembrane receptors in the human genome. The three program areas of this proposal will identify pH-selective agonists, inhibitors, modulators, drugs, and conformationally-selective nanobody probes for regulating and studying numerous human GPCRs.
StatusActive
Effective start/end date8/1/1611/30/22

Funding

  • National Institute of General Medical Sciences: $90,000.00
  • National Institute of General Medical Sciences: $378,400.00
  • National Institute of General Medical Sciences: $378,400.00
  • National Institute of General Medical Sciences: $1,982,000.00
  • National Institute of General Medical Sciences: $406,775.00

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