Molecular Mechanisms of Epilepsy-Causing Mutations in IKM channels: anti-epileptic effect of Lipophilic compounds.

Project: Research project

Project Details

Description

A growing number of inherited mutations have been found in the IKM (KCNQ2/KCNQ3) channels that cause epilepsy in patients. We recently determined that lipophilic compounds act on IKM channels with potential antiepileptic effects. We will here test more variants of these compounds on heterologously expressed channels and on human neurons derived from induced pluripotent stem cells (iPSC) expressing wild type and mutated KCNQ2 and KCNQ3 channels to establish which variants of these compounds can become new antiepileptic drugs.
StatusActive
Effective start/end date1/1/2012/31/22

Funding

  • National Institute of Neurological Disorders and Stroke: $302,203.00
  • National Institute of Neurological Disorders and Stroke: $676,679.00
  • National Institute of Neurological Disorders and Stroke: $38,696.00

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.